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. 2014 Jan 14;20(2):414–424. doi: 10.3748/wjg.v20.i2.414

Table 5.

Post transplant prophylaxis

Post transplant prophylaxis Comment
PJP prophylaxis Trimethoprim/sulfamethoxazole SS one tablet daily life long
Alternatives: Dapsone 100 mg daily, pentamidine 300 mg inhaled or iv monthly or atovaquone 1500 mg daily[54]
CMV Valganciclovir 900 mg daily1; oral (1 g tid) or iv (5 mg/kg daily) ganciclovir for 3 mo in D+/R-; prophylaxis or pre-emptive monitoring and therapy in R+
Fungal High risk patients2 should receive Fluconazole 400 mg po daily × 14 d minimum[100]
HBV (in HBV co-infected patients) Life long HBIG targeting 100 IU/L plus either tenofovir or entecavir
1

Valganciclovir is not FDA approved for use in liver transplantation; many centers use this agent off label[101];

2

High risk features include repeat or prolonged surgery, high transfusion requirements, renal failure, colonization with Candida or Choledochojejunostomy[100]. PJP: Pneumocystis jeroveci pneumonia; SS: Single strength; CMV: Cytomegalovirus; HBV: Hepatitis B virus; HBIG: Hepatitis B immunoglobulin; FDA: United States Food and Drug Administration.