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. 2014 Feb 12;9(2):e88722. doi: 10.1371/journal.pone.0088722

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© 2014 Zhou et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Immunohistochemistry of collagen I, which was mainly distributed in the adventitia of rat aortas (×200). (A)WKY, (B)SHR control, (C)SHR treated with Metoprolol, (D) SHR treated with Arotinolol. (E) Summarized data showing the changes in collagen contents of aortas in WKY, SHR control, SHRs treated with metoprolol or arotinolo by chloramine T and paradimethylaminobenzaldehyde method. *P<0.05 vs. SHR control, ^# P<0.05 vs. SHR treated with metoprolol. n = 12 in each group.