Table 1. Correlations between total, proline-hydroxylation and unhydroxylated HIF-1α and enzymes involved in HIF-1α degradation.

Pearson correlation p value	HIF-1α Pro402	HIF-1α Pro564	HydroxylatedHIF-1α	UnhydroxylatedHIF-1α	PHD1	PHD2	PHD3	VHL
HIF-1α	<0.0001 a	<0.0001 a	<0.0001 a	<0.0001 a	0.857	0.621	0.914	0.067
HIF-1α Pro402		<0.0001 a	<0.0001 a	0.030 b	0.140	0.830	0.695	0.766
HIF-1α Pro564			<0.0001 a	<0.0001 b	0.181	0.604	0.607	0.935
Hydroxylated HIF-1α				<0.0001 b	0.105	0.878	0.796	0.962
Unhydroxylated HIF-1α					0.085	0.785	0.545	0.030 a
PHD1						0.001 a	0.052	0.034 a
PHD2							<0.0001 a	0.100
PHD3								0.511
VHL

^asignificant positive correlation;

^bsignificant negative correlation.

The expression of PHD enzymes 1, 2 and 3 and VHL were scored and the expression correlated with HIF hydroxylation pattern using Pearson's correlation coefficient. Significant associations are in bold.