Figure 2. IRAK1 mosaicism blunts cytokine release following sepsis.

Animals were subjected to CLP, and 20 h later, blood (A and B) was collected and IL-6 and IL-10 concentrations determined. IL-6 was also measured in lung (C) and spleen (D). For comparison, responses from IRAK1-deficient homokaryotype mice are also shown. Insets show responses of WT mice with the indicated karyotype. Mean ± sem; n = 6–8. *Statistically significant difference compared with WT.