Table 1.
Analysis results from the MIST2 dataset
| tPA vs placebo (n = 98) | DNase vs placebo (n = 94) | tPA+DNase vs placebo (n = 98) | |
|---|---|---|---|
| Unadjusted for centre-effects |
|
|
|
| Patients included – no. (%) |
98 (100) |
94 (100) |
98 (100) |
| Odds ratio (95% CI) |
0.42 (0.09 to 1.87) |
2.72 (0.88 to 8.42) |
0.23 (0.04 to 1.29) |
| P-value |
0.25 |
0.08 |
0.10 |
| Fixed-effects |
|
|
|
| Patients included – no. (%) |
66 (67) |
80 (85) |
81 (83) |
| Odds ratio (95% CI) |
0.54 (0.12 to 2.56) |
3.34 (1.01 to 11.00) |
0.24 (0.04 to 1.36) |
| P-value |
0.44 |
0.048 |
0.11 |
| Random-effects |
|
|
|
| Patients included – no. (%) |
98 (100) |
94 (100) |
98 (100) |
| Odds ratio (95% CI) |
0.42 (0.09 to 1.87) |
2.72 (0.88 to 8.42) |
0.23 (0.04 to 1.29) |
| P-value |
0.25 |
0.08 |
0.10 |
| GEE* |
|
|
|
| Patients included – no. (%) |
98 (100) |
94 (100) |
98 (100) |
| Odds ratio (95% CI) |
0.33 (0.06 to 1.75) |
2.57 (0.76 to 8.66) |
0.18 (0.03 to 1.19) |
| P-value |
0.19 |
0.13 |
0.08 |
| Mantel-Haenszel |
|
|
|
| Patients included – no. (%) |
30 (31) |
45 (48) |
35 (36) |
| Odds ratio (95% CI) |
0.34 (0.05 to 2.15) |
3.59 (0.99 to 13.03) |
0.21 (0.02 to 1.98) |
| P-value | 0.27 | 0.04 | 0.13 |
*Convergence was not achieved.