Table 6.
Expression of proangiogenic factors and MVD according to the histopathological type of ovarian cancer
| Serous ovarian cancer (n = 22) | Mucinous ovarian cancer (n = 8) | Endometrioid ovarian cancer (n = 7) | Clear cell ovarian cancer (n = 4) | Undifferentiated carcinoma (n = 17) | P value | |
|---|---|---|---|---|---|---|
|
VEGF Median pg/mg protein (range, min–max) |
233.27 (0–3,000.0) | 512.8 (27.25–2,240.4) | 431.97 (166.20–2,298.3) | 1,070.8 (325.57–1,433.1) | 718.95 (10.14–3,000.0) | 0.152 |
|
EMMPRIN Median ng/mg protein (range, min–max) |
26.46 (10.65–88.22) | 25.81 (8.48–106.50) | 31.11 (13.35–60.43) | 34.96 (27.19–69.75) | 34.77 (10.86–90.28) | 0.874 |
|
bFGF Median ng/mg protein (range, min–max) |
1.03 (0.22–9.46) | 1.54 (0.17–3.60) | 0.81 (0.27–13.32) | 2.03 (0.19–5.93) | 0.94 (0.35–4.03) | 0.833 |
|
CD105-MVD Median vessels/mm2 (range, min–max) |
25 (0–38) | 19 (0–51) | 41 (13–51) | 25 (0–44) | 25 (0–57) | 0.573 |
|
CD31-MVD Median vessels/mm2 (range, min–max) |
73 (32–241) | 70 (19–95) | 101 (51–203) | 60 (44–82) | 63 (44–146) | 0.541 |
|
CD34-MVD Median vessels/mm2 (range, min–max) |
57 (6–165) | 57 (44–108) | 92 (57–146) | 57 (38–70) | 57 (6–190) | 0.585 |
CD105-MVD, CD31-MVD, and CD34-MVD refer to MVD assessed with antibodies against CD105, CD31, and CD34, respectively