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. 2014 Feb 13;5:39. doi: 10.3389/fimmu.2014.00039

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Copyright © 2014 Dwyer, Olynyk, Ramm and Tirnitz-Parker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The intrahepatic wound healing and regenerative niche in CDE-induced chronic liver injury in mice. Confocal microscopy of 2-week CDE-injured mouse liver shows the close association of PanCK⁺ liver progenitor cells with both αSMA⁺ activated hepatic stellate cells and CD45⁺ inflammatory cells. The spatial proximity of all three cell types suggests the potential for cellular cross-talk and co-regulation of the inflammatory, fibrogenic, and progenitor cell responses. Nuclei are stained with DAPI (blue). Scale bars represent 50 μm.