Table 5.
Vienna7 pupae vs. wild Hawaiian wild-type pupae differentially regulated genes GO term enrichment
| Term | Annotated | Significant | Expected | Fisher exact test | p-value |
|---|---|---|---|---|---|
|
Up-regulated genes
| |||||
| GO:0006412 |
Translation |
103 |
45 |
20.64 |
2.90E-08 |
| GO:0022900 |
Electron transport chain |
48 |
24 |
9.62 |
3.00E-06 |
| GO:0019079 |
Viral genome replication |
13 |
10 |
2.61 |
1.60E-05 |
| GO:0009409 |
Response to cold |
8 |
7 |
1.6 |
8.40E-05 |
| GO:0019058 |
Viral infectious cycle |
18 |
11 |
3.61 |
0.00016 |
| GO:0006091 |
Generation of precursor metabolites |
117 |
40 |
23.45 |
0.0002 |
| GO:0009631 |
Cold acclimation |
5 |
5 |
1 |
0.00032 |
| GO:0022904 |
Respiratory electron transport chain |
12 |
8 |
2.41 |
0.00058 |
| GO:0006626 |
Protein targeting to mitochondrion |
10 |
7 |
2 |
0.00086 |
| GO:0070585 |
Protein localization to mitochondrion |
10 |
7 |
2 |
0.00086 |
| GO:0072655 |
Establishment of protein localization |
10 |
7 |
2 |
0.00086 |
| GO:0065004 |
Protein-DNA complex assembly |
27 |
13 |
5.41 |
0.00093 |
| GO:0042773 |
ATP synthesis coupled electron transport |
8 |
6 |
1.6 |
0.00123 |
| GO:0042775 |
Mitochondrial ATP coupled electron transport |
8 |
6 |
1.6 |
0.00123 |
| GO:0044237 |
Vellular metabolic process |
2258 |
492 |
452.56 |
0.00136 |
| GO:0016032 |
Viral reproduction |
39 |
16 |
7.82 |
0.00211 |
| GO:0044764 |
Multi-organism cellular process |
39 |
16 |
7.82 |
0.00211 |
| GO:0008152 |
Metabolic process |
2745 |
586 |
550.16 |
0.00217 |
| GO:0016125 |
Sterol metabolic process |
36 |
15 |
7.22 |
0.0024 |
| GO:0007017 |
Microtubule-based process |
186 |
53 |
37.28 |
0.00298 |
| GO:0006119 |
Oxidative phosphorylation |
9 |
6 |
1.8 |
0.00307 |
| GO:0006767 |
Water-soluble vitamin metabolic process |
9 |
6 |
1.8 |
0.00307 |
| GO:0034660 |
NcRNA metabolic process |
74 |
25 |
14.83 |
0.00365 |
| GO:0006839 |
Mitochondrial transport |
21 |
10 |
4.21 |
0.00405 |
| GO:0006457 |
Protein folding |
52 |
19 |
10.42 |
0.00407 |
| GO:0042254 |
Ribosome biogenesis |
60 |
21 |
12.03 |
0.00467 |
| GO:0042982 |
Amyloid precursor protein metabolism |
7 |
5 |
1.4 |
0.00468 |
| GO:0045940 |
Positive regulation of steroid metabolism |
7 |
5 |
1.4 |
0.00468 |
| GO:0031047 |
Gene silencing by RNA |
28 |
12 |
5.61 |
0.00491 |
| GO:0015931 |
Nucleobase-containing compound transport |
53 |
19 |
10.62 |
0.00518 |
| GO:0009617 |
Response to bacterium |
72 |
24 |
14.43 |
0.00528 |
| GO:0044267 |
Cellular protein metabolic process |
609 |
146 |
122.06 |
0.00579 |
| GO:0000226 |
Microtubule cytoskeleton organization |
137 |
40 |
27.46 |
0.00594 |
| GO:0022415 |
Viral reproductive process |
32 |
13 |
6.41 |
0.00598 |
| GO:0007379 |
Segment specification |
22 |
10 |
4.41 |
0.00611 |
| GO:0008202 |
Steroid metabolic process |
54 |
19 |
10.82 |
0.00653 |
| GO:0001666 |
Response to hypoxia |
43 |
16 |
8.62 |
0.00663 |
| GO:0006379 |
mRNA cleavage |
5 |
4 |
1 |
0.00674 |
| GO:0034433 |
Steroid esterification |
5 |
4 |
1 |
0.00674 |
| GO:0034434 |
Sterol esterification |
5 |
4 |
1 |
0.00674 |
|
Down-regulated genes
| |||||
| GO:0065007 |
Biological regulation |
1938 |
577 |
429.5 |
5.50E-28 |
| GO:0050794 |
Regulation of cellular process |
1625 |
503 |
360.13 |
4.80E-27 |
| GO:0007154 |
Cell communication |
996 |
346 |
220.73 |
4.00E-26 |
| GO:0023052 |
Signaling |
980 |
341 |
217.19 |
8.30E-26 |
| GO:0044700 |
Single organism signaling |
980 |
341 |
217.19 |
8.30E-26 |
| GO:0050789 |
Regulation of biological process |
1780 |
533 |
394.48 |
4.40E-25 |
| GO:0003008 |
System process |
462 |
185 |
102.39 |
2.30E-20 |
| GO:0048646 |
Anatomical structure formation |
662 |
240 |
146.71 |
9.10E-20 |
| GO:0044699 |
Single-organism process |
2913 |
755 |
645.58 |
1.90E-19 |
| GO:0044763 |
Single-organism cellular process |
2412 |
653 |
534.55 |
2.50E-19 |
| GO:0009653 |
Anatomical structure morphogenesis |
761 |
265 |
168.65 |
3.80E-19 |
| GO:0050877 |
Neurological system process |
385 |
158 |
85.32 |
1.50E-18 |
| GO:0048468 |
Cell development |
610 |
222 |
135.19 |
2.20E-18 |
| GO:0007165 |
Signal transduction |
804 |
274 |
178.18 |
2.40E-18 |
| GO:0044707 |
Single-multicellular organism process |
1699 |
491 |
376.53 |
7.30E-18 |
| GO:0044767 |
Single-organism developmental process |
1185 |
369 |
262.62 |
7.60E-18 |
| GO:0030182 |
Neuron differentiation |
331 |
140 |
73.36 |
8.60E-18 |
| GO:0032501 |
Multicellular organismal process |
1737 |
497 |
384.95 |
4.10E-17 |
| GO:0048513 |
Organ development |
697 |
242 |
154.47 |
4.10E-17 |
| GO:0010646 |
Regulation of cell communication |
412 |
161 |
91.31 |
1.90E-16 |
| GO:0035556 |
Intracellular signal transduction |
359 |
145 |
79.56 |
2.90E-16 |
| GO:0048731 |
System development |
1025 |
324 |
227.16 |
2.90E-16 |
| GO:0023051 |
Regulation of signaling |
417 |
162 |
92.42 |
2.90E-16 |
| GO:0048699 |
Generation of neurons |
356 |
144 |
78.9 |
3.20E-16 |
| GO:0007267 |
Cell-cell signaling |
264 |
115 |
58.51 |
8.30E-16 |
| GO:0007268 |
Synaptic transmission |
181 |
88 |
40.11 |
9.20E-16 |
| GO:0048856 |
Anatomical structure development |
1301 |
389 |
288.33 |
1.60E-15 |
| GO:0009887 |
Organ morphogenesis |
316 |
130 |
70.03 |
2.30E-15 |
| GO:0032989 |
Cellular component morphogenesis |
362 |
143 |
80.23 |
4.50E-15 |
| GO:0016043 |
Cellular component organization |
1160 |
353 |
257.08 |
4.90E-15 |
| GO:0050793 |
Regulation of developmental process |
339 |
135 |
75.13 |
1.40E-14 |
| GO:0007275 |
Multicellular organismal development |
1356 |
398 |
300.52 |
1.90E-14 |
| GO:0030154 |
Cell differentiation |
927 |
292 |
205.44 |
3.70E-14 |
| GO:0035637 |
Multicellular organismal signaling |
206 |
93 |
45.65 |
4.60E-14 |
| GO:0019226 |
Transmission of nerve impulse |
203 |
92 |
44.99 |
4.70E-14 |
| GO:0000904 |
Cell morphogenesis involved in different… |
249 |
106 |
55.18 |
8.40E-14 |
| GO:0009966 |
Regulation of signal transduction |
363 |
140 |
80.45 |
9.10E-14 |
| GO:0007399 |
Nervous system development |
617 |
210 |
136.74 |
1.20E-13 |
| GO:0048666 |
Neuron development |
294 |
119 |
65.16 |
1.70E-13 |
| GO:0000902 |
Cell morphogenesis |
315 |
125 |
69.81 |
2.10E-13 |
| GO:0048869 | Cellular developmental process | 964 | 298 | 213.64 | 3.00E-13 |