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. 2014 Feb 5;15:98. doi: 10.1186/1471-2164-15-98

Table 5.

Vienna7 pupae vs. wild Hawaiian wild-type pupae differentially regulated genes GO term enrichment

Term Annotated Significant Expected Fisher exact test p-value
Up-regulated genes
GO:0006412
Translation
103
45
20.64
2.90E-08
GO:0022900
Electron transport chain
48
24
9.62
3.00E-06
GO:0019079
Viral genome replication
13
10
2.61
1.60E-05
GO:0009409
Response to cold
8
7
1.6
8.40E-05
GO:0019058
Viral infectious cycle
18
11
3.61
0.00016
GO:0006091
Generation of precursor metabolites
117
40
23.45
0.0002
GO:0009631
Cold acclimation
5
5
1
0.00032
GO:0022904
Respiratory electron transport chain
12
8
2.41
0.00058
GO:0006626
Protein targeting to mitochondrion
10
7
2
0.00086
GO:0070585
Protein localization to mitochondrion
10
7
2
0.00086
GO:0072655
Establishment of protein localization
10
7
2
0.00086
GO:0065004
Protein-DNA complex assembly
27
13
5.41
0.00093
GO:0042773
ATP synthesis coupled electron transport
8
6
1.6
0.00123
GO:0042775
Mitochondrial ATP coupled electron transport
8
6
1.6
0.00123
GO:0044237
Vellular metabolic process
2258
492
452.56
0.00136
GO:0016032
Viral reproduction
39
16
7.82
0.00211
GO:0044764
Multi-organism cellular process
39
16
7.82
0.00211
GO:0008152
Metabolic process
2745
586
550.16
0.00217
GO:0016125
Sterol metabolic process
36
15
7.22
0.0024
GO:0007017
Microtubule-based process
186
53
37.28
0.00298
GO:0006119
Oxidative phosphorylation
9
6
1.8
0.00307
GO:0006767
Water-soluble vitamin metabolic process
9
6
1.8
0.00307
GO:0034660
NcRNA metabolic process
74
25
14.83
0.00365
GO:0006839
Mitochondrial transport
21
10
4.21
0.00405
GO:0006457
Protein folding
52
19
10.42
0.00407
GO:0042254
Ribosome biogenesis
60
21
12.03
0.00467
GO:0042982
Amyloid precursor protein metabolism
7
5
1.4
0.00468
GO:0045940
Positive regulation of steroid metabolism
7
5
1.4
0.00468
GO:0031047
Gene silencing by RNA
28
12
5.61
0.00491
GO:0015931
Nucleobase-containing compound transport
53
19
10.62
0.00518
GO:0009617
Response to bacterium
72
24
14.43
0.00528
GO:0044267
Cellular protein metabolic process
609
146
122.06
0.00579
GO:0000226
Microtubule cytoskeleton organization
137
40
27.46
0.00594
GO:0022415
Viral reproductive process
32
13
6.41
0.00598
GO:0007379
Segment specification
22
10
4.41
0.00611
GO:0008202
Steroid metabolic process
54
19
10.82
0.00653
GO:0001666
Response to hypoxia
43
16
8.62
0.00663
GO:0006379
mRNA cleavage
5
4
1
0.00674
GO:0034433
Steroid esterification
5
4
1
0.00674
GO:0034434
Sterol esterification
5
4
1
0.00674
Down-regulated genes
GO:0065007
Biological regulation
1938
577
429.5
5.50E-28
GO:0050794
Regulation of cellular process
1625
503
360.13
4.80E-27
GO:0007154
Cell communication
996
346
220.73
4.00E-26
GO:0023052
Signaling
980
341
217.19
8.30E-26
GO:0044700
Single organism signaling
980
341
217.19
8.30E-26
GO:0050789
Regulation of biological process
1780
533
394.48
4.40E-25
GO:0003008
System process
462
185
102.39
2.30E-20
GO:0048646
Anatomical structure formation
662
240
146.71
9.10E-20
GO:0044699
Single-organism process
2913
755
645.58
1.90E-19
GO:0044763
Single-organism cellular process
2412
653
534.55
2.50E-19
GO:0009653
Anatomical structure morphogenesis
761
265
168.65
3.80E-19
GO:0050877
Neurological system process
385
158
85.32
1.50E-18
GO:0048468
Cell development
610
222
135.19
2.20E-18
GO:0007165
Signal transduction
804
274
178.18
2.40E-18
GO:0044707
Single-multicellular organism process
1699
491
376.53
7.30E-18
GO:0044767
Single-organism developmental process
1185
369
262.62
7.60E-18
GO:0030182
Neuron differentiation
331
140
73.36
8.60E-18
GO:0032501
Multicellular organismal process
1737
497
384.95
4.10E-17
GO:0048513
Organ development
697
242
154.47
4.10E-17
GO:0010646
Regulation of cell communication
412
161
91.31
1.90E-16
GO:0035556
Intracellular signal transduction
359
145
79.56
2.90E-16
GO:0048731
System development
1025
324
227.16
2.90E-16
GO:0023051
Regulation of signaling
417
162
92.42
2.90E-16
GO:0048699
Generation of neurons
356
144
78.9
3.20E-16
GO:0007267
Cell-cell signaling
264
115
58.51
8.30E-16
GO:0007268
Synaptic transmission
181
88
40.11
9.20E-16
GO:0048856
Anatomical structure development
1301
389
288.33
1.60E-15
GO:0009887
Organ morphogenesis
316
130
70.03
2.30E-15
GO:0032989
Cellular component morphogenesis
362
143
80.23
4.50E-15
GO:0016043
Cellular component organization
1160
353
257.08
4.90E-15
GO:0050793
Regulation of developmental process
339
135
75.13
1.40E-14
GO:0007275
Multicellular organismal development
1356
398
300.52
1.90E-14
GO:0030154
Cell differentiation
927
292
205.44
3.70E-14
GO:0035637
Multicellular organismal signaling
206
93
45.65
4.60E-14
GO:0019226
Transmission of nerve impulse
203
92
44.99
4.70E-14
GO:0000904
Cell morphogenesis involved in different…
249
106
55.18
8.40E-14
GO:0009966
Regulation of signal transduction
363
140
80.45
9.10E-14
GO:0007399
Nervous system development
617
210
136.74
1.20E-13
GO:0048666
Neuron development
294
119
65.16
1.70E-13
GO:0000902
Cell morphogenesis
315
125
69.81
2.10E-13
GO:0048869 Cellular developmental process 964 298 213.64 3.00E-13