Table 6.
Vienna7 adults vs. wild Hawaiian wild-type adults differentially regulated genes GO term enrichment
| Term | Annotated | Significant | Expected | Fisher exact test | p-value |
|---|---|---|---|---|---|
|
Up-regulated genes
| |||||
| GO:0044260 |
Cellular macromolecule metabolic process |
1441 |
270 |
190.73 |
7.90E-14 |
| GO:0006396 |
RNA processing |
166 |
56 |
21.97 |
3.50E-12 |
| GO:0044237 |
Cellular metabolic process |
2258 |
372 |
298.87 |
1.40E-11 |
| GO:0022613 |
Ribonucleoprotein complex biogenesis |
73 |
31 |
9.66 |
4.60E-10 |
| GO:0043170 |
Macromolecule metabolic process |
1839 |
311 |
243.41 |
5.20E-10 |
| GO:0008152 |
Metabolic process |
2745 |
425 |
363.33 |
1.40E-09 |
| GO:0034660 |
ncRNA metabolic process |
74 |
30 |
9.79 |
3.40E-09 |
| GO:0071704 |
Organic substance metabolic process |
2587 |
403 |
342.41 |
6.90E-09 |
| GO:0042254 |
Ribosome biogenesis |
60 |
26 |
7.94 |
7.30E-09 |
| GO:0006364 |
rRNA processing |
35 |
19 |
4.63 |
8.00E-09 |
| GO:0034470 |
ncRNA processing |
53 |
24 |
7.02 |
9.60E-09 |
| GO:0016072 |
rRNA metabolic process |
36 |
19 |
4.76 |
1.50E-08 |
| GO:0044238 |
Primary metabolic process |
2432 |
382 |
321.9 |
1.70E-08 |
| GO:0090304 |
Nucleic acid metabolic process |
948 |
175 |
125.48 |
1.20E-07 |
| GO:0006457 |
Protein folding |
52 |
22 |
6.88 |
1.80E-07 |
| GO:0034641 |
Cellular nitrogen compound metabolism |
1291 |
221 |
170.88 |
8.10E-07 |
| GO:0046483 |
Heterocycle metabolic process |
1212 |
209 |
160.42 |
1.20E-06 |
| GO:0006725 |
Cellular aromatic compound metabolism |
1231 |
211 |
162.93 |
1.60E-06 |
| GO:0006139 |
Nucleobase-containing compound metabolism |
1166 |
201 |
154.33 |
2.30E-06 |
| GO:0044267 |
Cellular protein metabolic process |
609 |
118 |
80.61 |
2.50E-06 |
| GO:1901360 |
Organic cyclic compound metabolism |
1289 |
218 |
170.61 |
2.90E-06 |
| GO:0006974 |
Response to DNA damage stimulus |
136 |
38 |
18 |
3.00E-06 |
| GO:0000075 |
Cell cycle checkpoint |
44 |
18 |
5.82 |
4.30E-06 |
| GO:0031570 |
DNA integrity checkpoint |
33 |
15 |
4.37 |
5.80E-06 |
| GO:0030163 |
Protein catabolic process |
110 |
32 |
14.56 |
7.30E-06 |
| GO:0044265 |
Cellular macromolecule catabolic process |
143 |
38 |
18.93 |
1.10E-05 |
| GO:0071156 |
Regulation of cell cycle arrest |
47 |
18 |
6.22 |
1.30E-05 |
| GO:0000077 |
DNA damage checkpoint |
28 |
13 |
3.71 |
1.90E-05 |
| GO:0009451 |
RNA modification |
18 |
10 |
2.38 |
2.50E-05 |
| GO:0007050 |
Cell cycle arrest |
58 |
20 |
7.68 |
2.70E-05 |
| GO:0016071 |
mRNA metabolic process |
122 |
33 |
16.15 |
2.80E-05 |
| GO:0051603 |
Proteolysis involved in cellular protein… |
88 |
26 |
11.65 |
4.00E-05 |
| GO:0006807 |
Nitrogen compound metabolic process |
1455 |
234 |
192.58 |
5.70E-05 |
| GO:0006270 |
DNA replication initiation |
10 |
7 |
1.32 |
5.70E-05 |
| GO:0044257 |
Cellular protein catabolic process |
90 |
26 |
11.91 |
6.10E-05 |
| GO:0019079 |
Viral genome replication |
13 |
8 |
1.72 |
6.30E-05 |
| GO:0007093 |
Mitotic cell cycle checkpoint |
31 |
13 |
4.1 |
7.00E-05 |
| GO:0022403 |
Cell cycle phase |
246 |
54 |
32.56 |
7.10E-05 |
| GO:0009057 |
Macromolecule catabolic process |
201 |
46 |
26.6 |
8.70E-05 |
| GO:0010389 |
Regulation of G2/M transition of mitotic… |
28 |
12 |
3.71 |
0.0001 |
| GO:0051329 |
Interphase of mitotic cell cycle |
73 |
22 |
9.66 |
0.00011 |
|
Down-regulated genes
| |||||
| GO:0071482 |
Cellular response to light stimulus |
14 |
11 |
1.59 |
9.80E-09 |
| GO:0007603 |
Phototransduction, visible light |
10 |
9 |
1.14 |
2.70E-08 |
| GO:0016056 |
Rhodopsin mediated signaling pathway |
10 |
9 |
1.14 |
2.70E-08 |
| GO:0048646 |
Anatomical structure formation involved… |
662 |
118 |
75.31 |
4.80E-08 |
| GO:0007600 |
Sensory perception |
142 |
39 |
16.15 |
6.40E-08 |
| GO:0009583 |
Detection of light stimulus |
29 |
15 |
3.3 |
9.60E-08 |
| GO:0009584 |
Detection of visible light |
19 |
12 |
2.16 |
9.80E-08 |
| GO:0042692 |
Muscle cell differentiation |
123 |
35 |
13.99 |
1.20E-07 |
| GO:0001539 |
Ciliary or flagellar motility |
11 |
9 |
1.25 |
1.30E-07 |
| GO:0051239 |
Regulation of multicellular organismal processes |
413 |
81 |
46.98 |
1.70E-07 |
| GO:0003008 |
System process |
462 |
88 |
52.55 |
1.90E-07 |
| GO:0009581 |
Detection of external stimulus |
38 |
17 |
4.32 |
2.00E-07 |
| GO:0016059 |
Deactivation of rhodopsin mediated signa… |
9 |
8 |
1.02 |
2.20E-07 |
| GO:0022400 |
Regulation of rhodopsin mediated signali… |
9 |
8 |
1.02 |
2.20E-07 |
| GO:0009582 |
Detection of abiotic stimulus |
39 |
17 |
4.44 |
3.20E-07 |
| GO:0055002 |
Striated muscle cell development |
86 |
27 |
9.78 |
4.00E-07 |
| GO:0007602 |
Phototransduction |
21 |
12 |
2.39 |
4.60E-07 |
| GO:0055001 |
Muscle cell development |
92 |
28 |
10.47 |
5.00E-07 |
| GO:0030239 |
Myofibril assembly |
36 |
16 |
4.1 |
5.10E-07 |
| GO:0061061 |
Muscle structure development |
174 |
42 |
19.79 |
9.80E-07 |
| GO:0050953 |
Sensory perception of light stimulus |
70 |
23 |
7.96 |
1.20E-06 |
| GO:0051606 |
Setection of stimulus |
48 |
18 |
5.46 |
2.10E-06 |
| GO:0071478 |
Cellular response to radiation |
20 |
11 |
2.28 |
2.40E-06 |
| GO:0007018 |
Microtubule-based movement |
53 |
19 |
6.03 |
2.40E-06 |
| GO:0007601 |
Visual perception |
68 |
22 |
7.74 |
2.80E-06 |
| GO:0050877 |
Neurological system process |
385 |
73 |
43.8 |
3.00E-06 |
| GO:0048468 |
Cell development |
610 |
104 |
69.39 |
3.70E-06 |
| GO:0009653 |
Anatomical structure morphogenesis |
761 |
124 |
86.57 |
3.80E-06 |
| GO:0044707 |
Single-multicellular organism process |
1699 |
239 |
193.27 |
4.80E-06 |
| GO:0051146 |
Striated muscle cell differentiation |
108 |
29 |
12.29 |
5.40E-06 |
| GO:0030182 |
Neuron differentiation |
331 |
64 |
37.65 |
6.90E-06 |
| GO:0032501 |
Multicellular organismal process |
1737 |
242 |
197.59 |
9.10E-06 |
| GO:0031032 |
Actomyosin structure organization |
44 |
16 |
5.01 |
1.20E-05 |
| GO:0040011 |
Locomotion |
380 |
70 |
43.23 |
1.40E-05 |
| GO:0009416 |
Response to light stimulus |
55 |
18 |
6.26 |
1.90E-05 |
| GO:0032101 |
Regulation of response to external stimuli |
55 |
18 |
6.26 |
1.90E-05 |
| GO:0071214 |
Cellular response to abiotic stimulus |
28 |
12 |
3.19 |
2.20E-05 |
| GO:0007606 |
Sensory perception of chemical stimulus |
56 |
18 |
6.37 |
2.50E-05 |
| GO:0032989 |
Cellular component morphogenesis |
362 |
66 |
41.18 |
3.70E-05 |
| GO:0048699 |
generation of neurons |
356 |
65 |
40.5 |
4.10E-05 |
| GO:2000026 | Regulation of multicellular organismal development | 228 | 46 | 25.94 | 5.10E-05 |