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. Author manuscript; available in PMC: 2014 Feb 13.
Published in final edited form as: Sci Signal. 2013 Aug 20;6(289):ra72. doi: 10.1126/scisignal.2003801

Fig. 6. DOK3 KO mice exhibit increased TNF-α production and mortality in response to challenge with a sublethal dose of LPS.

Fig. 6

(A) DOK3 KO and control S129 mice were treated with a sublethal dose of LPS by intraperitoneal injection and were monitored for survival over the next 6 days. DOK3 KO mice had statistically significantly increased mortality [P < 0.005, log-rank (Mantel-Cox) test] compared to S129 mice. Data are from three experiments with a total of 24 S129 mice and 22 DOK3 KO mice. (B) Sera were collected from control and DOK3 KO mice 40 min after challenge with LPS (10 mg/kg). TNF-α concentrations were measured by ELISA (P = 0.1102, unpaired t test). Data are from two experiments with a total of nine WT and eight DOK3 KO mice.