Table 1.
Human seminal fluid proteases.
| Protease class | Protein name | GI | References |
|---|---|---|---|
| ADAM metalloprotease | |||
| ADAMTS-1 | 1264483 | (Pilch and Mann 2006) | |
| ADAM 7 | 296439449 | (Pilch and Mann 2006) | |
|
| |||
| Aminopeptidase | |||
| LAP3 | 48146373 | (Pilch and Mann 2006) | |
| Aminoacylproline aminopeptidase | 68566146 | (Pilch and Mann 2006) | |
| Aminopeptidase N | 143811362 | (Pilch and Mann 2006; Utleg et al. 2003) | |
|
| |||
| Asparaginyl peptidase | |||
| Legumain | 56682964 | (Pilch and Mann 2006) | |
|
| |||
| Aspartate | |||
| Gastricin | 129796 | (Fung et al. 2004; Utleg et al. 2003) | |
|
| |||
| Carboxypeptidase | |||
| Carboxypeptidase C | 11055992 | (Pilch and Mann 2006) | |
| Carboxypeptidase D | 25089854 | (Pilch and Mann 2006) | |
| Carboxypeptidase E | 4503009 | (Pilch and Mann 2006) | |
| Carboxypeptidase M | 53832021 | (Pilch and Mann 2006) | |
| Carboxypeptidase O | 27436871 | (Pilch and Mann 2006) | |
| Carboxypeptidase Z | 62388875 | (Pilch and Mann 2006) | |
| Glutamate carboxypeptidase-like protein 1 | 23396498 | (Pilch and Mann 2006) | |
| Pancreatic carboxypeptidase B1 | 54607080 | (Pilch and Mann 2006) | |
| Probable serine carboxypeptidase CPVL precursor | 67476930 | (Pilch and Mann 2006) | |
| Prolylcarboxypeptidase | 4826940 | (Pilch and Mann 2006) | |
| Glutamate carboxyeptidase (CPGL) | 15620780 | (Utleg et al. 2003) | |
|
| |||
| Caspase | |||
| Caspase 14 | 6912286 | (Pilch and Mann 2006) | |
| Paracaspase | 20455075 | (Pilch and Mann 2006) | |
|
| |||
| Papain-like cysteine | |||
| Cathepsin B | 22538437 | (Pilch and Mann 2006) | |
| Cathepsin D | 4503143 | (Pilch and Mann 2006) | |
| Cathepsin F | 6042196 | (Pilch and Mann 2006) | |
| Cathepsin G | 4503149 | (Pilch and Mann 2006) | |
| Cathepsin H | 21264388 | (Pilch and Mann 2006) | |
| Cathepsin O | 4557501 | (Pilch and Mann 2006) | |
| Cathepsin L1 | 22202619 | (Pilch and Mann 2006) | |
| Cathepsin Z | 22538442 | (Pilch and Mann 2006) | |
| PPGB | 56001072 | (Pilch and Mann 2006) | |
|
| |||
| Other cysteine | |||
| Calpain 1 | 12408656 | (Pilch and Mann 2006) | |
|
| |||
| Matrix metalloprotease | |||
| MMP2 | 11342666 | (Pilch and Mann 2006) | |
| MMP7 | 4505219 | (Pilch and Mann 2006) | |
| MMP14 | 317373419 | (Pilch and Mann 2006) | |
|
| |||
| Other Peptidase | |||
| Dipeptidase 3 | 193211608 | (Pilch and Mann 2006) | |
| Dipeptidyl-peptidase II | 21617867 | (Pilch and Mann 2006) | |
| Dipeptidyl-peptidase III | 20532389 | (Pilch and Mann 2006) | |
| Tripeptidyl-peptidase I | 62896635 | (Pilch and Mann 2006) | |
| Tripeptidyl peptidase II | 55661754 | (Pilch and Mann 2006) | |
| Peptidase A | 23396498 | (Pilch and Mann 2006) | |
| Puromycin-sensitive aminopeptidase | 51704228 | (Pilch and Mann 2006) | |
| Insulin protease | 215274252 | (Pilch and Mann 2006) | |
| Dipeptidyl peptidase IV | 1352311 | (Pilch and Mann 2006; Utleg et al. 2003) | |
| Neprilysin | 128062 | (Utleg et al. 2003) | |
|
| |||
| Serine | |||
| KLK12 | 37182171 | (Yousef and Diamandis 2001) | |
| KLK14 | 156257445 | (Yousef and Diamandis 2001) | |
| KLK15 | 9957760 | (Yousef and Diamandis 2001) | |
| KLK4 | 64653115 | (Yousef and Diamandis 2001) | |
| KLK5 | 37183138 | (Yousef and Diamandis 2001) | |
| KLK8 | 37183190 | (Yousef and Diamandis 2001) | |
| KLK11 | 5803199 | (Pilch and Mann 2006; Yousef and Diamandis 2001) | |
| KLK2 | 5031829 | (Pilch and Mann 2006; Yousef and Diamandis 2001) | |
| Acrosin light chain | 115502349 | (Pilch and Mann 2006) | |
| Brain-specific serine protease 4 | 11545839 | (Pilch and Mann 2006) | |
| C1r-like serine protease analog protein | 182705204 | (Pilch and Mann 2006) | |
| complement component 1 | 62897163 | (Pilch and Mann 2006) | |
| complement component 2 | 74755562 | (Pilch and Mann 2006) | |
| complement factor B | 67782358 | (Pilch and Mann 2006) | |
| complement factor I | 317373341 | (Pilch and Mann 2006) | |
| matriptase | 13124575 | (Pilch and Mann 2006) | |
| prostasin | 4506153 | (Pilch and Mann 2006) | |
| serine protease 1 | 4506145 | (Pilch and Mann 2006) | |
| TMPRSS2 | 115502469 | (Pilch and Mann 2006; Utleg et al. 2003) | |
| PSA (KLK3) | 4502173 | (Fung et al. 2004; Pilch and Mann 2006; Utleg et al. 2003) | |
|
| |||
| Thermolysin-like | |||
| Angiotensin I converting enzyme | 4503273 | (Pilch and Mann 2006) | |
| Angiotensin-converting enzyme 2 | 48525714 | (Pilch and Mann 2006) | |
|
| |||
| Ubiquitin processing | |||
| Deubiquitinating enzyme 14 | 1729927 | (Pilch and Mann 2006) | |
Proteases identified in human seminal plasma or prostasomes, listed by protease class. Classes are based either on experimental data or computational prediction. GI: NCBI identifier.