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. Author manuscript; available in PMC: 2015 Jan 16.
Published in final edited form as: Vaccine. 2013 Dec 7;32(4):483–491. doi: 10.1016/j.vaccine.2013.11.058

Figure 1. ITV induces larger effector, memory, and permits higher secondary CD8 T cell responses than RAS vaccination in B6 mice.

Figure 1

B6 mice were immunized with 104 Py either as RAS or ITV with 10 days CQ chemoprophylaxis. Arrows indicate day of vaccination or rechallenge. (A), Representative CD8 T cell responses in blood at the indicated days post vaccination. Numbers indicate the frequency of CD8 T cells exhibiting an antigen-experienced (CD8αint, CD11ahi) phenotype. (B), Cumulative and kinetic analysis of ITV versus RAS vaccine-induced CD8 T cell responses. Secondary effector responses were measured after administration of 104 virulent sporozoites on day 68. Data are Mean +/− SD for 30 mice (through d68) and 10 mice (d68 to d88). **, P <0.0001; *, P = 0.00143.