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. Author manuscript; available in PMC: 2015 Jan 16.
Published in final edited form as: Vaccine. 2013 Dec 7;32(4):483–491. doi: 10.1016/j.vaccine.2013.11.058

Table 1.

Single-dose infection-treatment vaccination (ITV) provides sterilizing protection from Py sporozoite challenge in B6 mice.

Attenuated Sporozoite
Vaccinationa 		Day challenged
post-vaccination		 % Sterilizing
protectionb
Naive+CQc N/A 0% (0/10)
10,000 RAS 62 days 0% (0/10)
10,000 ITV 62 days 90% (9/10)
a

Age matched C57BL/6 female mice were vaccinated I.V. with 104 P. yoelii RAS or with virulent P. yoelii 17XNL sporozoites plus once daily I.P. injection of CQ for 10 ays, (ITV).

b

Sterilizing protection is defined as complete absence of detectable blood-stage parasitemia when assessed on days 3, 5, 7, 9 and 10 post-challenge with 103 P. yoelii sporozoites.

c

Naive C57Bl/6 female mice were administered CQ similarly as ITV group.