Table 5.
Dose–response relations between serum indium and KL-6, SP-D, and interstitial changes on chest HRCT
| |
Serum indium (μg/L) |
KL-6 (U/mL) |
SP-D (ng/mL) |
Prevalence (%) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Group | Range | GM | n | GM | GSD | GM | GSD | KL-6 (>500 U/mL) | SP-D (>110 ng/mL) | HRCT-I |
| 0 |
<1.0 |
0.2 |
3 |
586.1 |
1.3 |
120.9 |
2.9 |
100.0 |
33.3 |
0.0 |
| 1 |
1.0-4.9 |
3.4 |
7 |
509.6 |
1.7 |
143.8 |
1.5 |
42.9 |
71.4 |
14.3 |
| 2 |
5.0-9.9 |
7.4 |
6 |
1126.9 |
1.6 |
132.5 |
1.6 |
83.3 |
66.7 |
33.3 |
| 3 |
10.0-29.9 |
15.5 |
6 |
486.3 |
1.4 |
157.6 |
1.6 |
50.0 |
83.3 |
16.7 |
| 4 |
30.0-49.9 |
43.8 |
5 |
1539.4* |
1.5 |
252.6 |
1.9 |
100.0 |
80.0 |
40.0 |
| 5 |
≧50 |
81.5 |
7 |
1451.1* |
1.1 |
299.8 |
1.3 |
100.0 |
100.0 |
42.7 |
| p for trend | 0.0055 | 0.0005 | 0.1057 | 0.0353 | 0.1198 | |||||
Abbreviations: GM geometric mean, GSD geometric standard deviation, KL-6 Krebs von den Lungen-6, SP-D surfactant protein D, HRCT-I interstitial changes on HRCT, Prevalence (%): % of workers exceeding each reference values and % of workers with interstitial changes on HRCT, p for trend: age- and smoking-adjusted multiple regression model for GM and GSD of KL-6 and SP-D, Mantel-Haenszel trend for prevalence data, * P < 0.05 by Dunnett’s test.