Table 1.
Description and Values of the Mathematical Model Parameters
| Biological Process | Symbol | Original Parameter | Second Iteration | Final Iteration |
|---|---|---|---|---|
| Per Gy production of lethal DNA lesions from single-radiation track in DSC and SLRC | αd/αs | 0.0987/0.0395 | 0.0987/0.0429 | 0.0987/0.00987 |
| Per Gy2 production of lethal DNA lesions from two radiation tracks in DSC and SLRC | βd/βs | 1.14 × 10−7/4.58 × 10−8 | 1.14 × 10−7/4.96 × 10−8 | 1.14 × 10−7/1.14 × 10−8 |
| Rate at which newly converted DSC lead to clonal expansion (hr) | η d | 0.5 | 0.092 | 0.054 |
| Minimum time for newly converted DSC to being clonal expansion (hr) | Md | 24 | 313.256 | 366.3 |
| Minimum time DSC and SLRC are in quiescence (hr) | Ld/Ls | 24/36 | 461.46/464.99 | 193.32/477.02 |
| Rate at which DSC and SLRC exit quiescence | λd/λs | 0.5/0.35 | .011/.0001 | .1/.0328 |
| Proliferation rate of DSC and SLRC after exiting quiescence | rd/rs | .0088/.0001 | .0057/.0001 | .0038/.0008 |
| Initial ratio of DSC to SLRC | R | 20 | 20 | 20 |
| Rate at which SLRC convert to DSC | as | 0.0001 | 0.0001 | 0.0019 |
| Rate of reversion of DSC to SLRC | ν | 1.15 | 3.64 | 0.45 |
| Fraction of DSC capable of reverting to SLRC | γ | 0.15 | 0.353 | 0.4 |
| Time to peak reversion after irradiation | μ | - | 3.5 | 3.25 |
| Width of window of reversion | σ 2 | - | 2.5548 | 1.46 |