Table 2.
EC50 of sigma-2 ligands in EMT-6 and MDA-MB-435 cell lines using MTS assay
| EMT-6 | MDA-MB-435 | |||
|---|---|---|---|---|
|
| ||||
| Compound | EC50 (μM, 24h) | EC50 (μM, 48h) | EC50 (μM, 24h) | EC50 (μM, 48h) |
| Azabicyclononane Analogs | ||||
| SV119 | 16.0 ± 1.4 | 11.4 ± 1.7 | 36.7 ± 3.3 | 18.5 ± 1.9 |
| SV166 | 30.0 ± 1.0 | 18.5 ± 2.1 | 34.1 ± 4.4 | 25.0 ± 5.57 |
| WC-26 | 42.5 ± 3.5 | 12.3 ± 1.6 | 49.7 ± 2.5 | 44.9 ± 5.3 |
| 2b | 65.5 ± 7.1 | 29 ± 1.4 | 63.1 ± 5.8 | 33.3 ± 3.26 |
| YUN245 | >200 | 154.5 ± 30.4 | 136.9 ± 4.6 | 101.0 ± 15.1 |
| SV95 | >200 | >200 | >200 | >200 |
| Benzamide Analogs | ||||
| RHM-1 | >200 | >200 | >200 | >200 |
| ISO-1 | >200 | >200 | >200 | >200 |
| YUN234 | >200 | 91 ± 12.7 | >200 | >200 |
| YUN252 | >200 | 137.5 ± 3.5 | >200 | >200 |
| Tropane Analog | ||||
| Siramesine Analog | ||||
| siramesine | 14.9 ± 4.0 | 5.3 ± 1.0 | 9.4 ± 0.4 | 9.3 ± 0.9 |