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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Anal Biochem. 2013 Dec 12;448:68–74. doi: 10.1016/j.ab.2013.12.008

Table 3.

EC50 of sigma-2 ligands in EMT-6 and MDA-MB-435 cell lines using caspase-3 activity assay

EMT-6 MDA-MB-435
Compound EC50 (μM, 24h) EC50 (μM, 24h)
Azabicyclononane Analogs
SV119 11.6 ± 3.7 35.6 ± 2.97
SV166 34.8 ± 4.7 30.4 ± 1.0
WC-26 51.8 ± 4.4 67.4 ± 0.5
2b 62.2 ± 3.3 75.2 ± 2.1
YUN245 175.2 ± 25.5 119.4 ± 10.3
SV95 > 200 >200
Benzamide Analogs
RHM-1 >200 >200
ISO-1 >200 >200
YUN234 >200 >200
YUN252 >200 >200
Tropane Analog
RHM-138 40.8 ± 4.2 52.7 ± 1.2
Siramesine Analog
siramesine 15.9 ± 2.7 9.9 ± 2.8