Table 1.
Pathological and functional consequences of unilateral injury to the parietal versus frontal lobe in the p21 mouse.
| Pathology/behavior | Parietal injury | Frontal injury |
|---|---|---|
| Cell death and neuronal loss | + | + |
| - frontal cortex | - | + |
| - parietal cortex | + | - |
| - hippocampus | + | - |
| - dorsal striatum | - | + |
| - dorsal thalamus | + | - |
| - anterior corpus callosum | - | + |
| - posterior corpus callosum | + | - |
| Reactive gliosis | + | + |
| Axonal injury | + | + |
| Hyperactivity | + | - |
| Memory deficits | + | - |
| Social deficits | + | - |
| Anxiety | +/- | - |
| Motor deficits | - | + |