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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Methods. 2013 Jun 27;62(2):177–181. doi: 10.1016/j.ymeth.2013.05.020

Figure 1.

Figure 1

H2S biosynthesis and degradation, along with a comparison of pathways that contribute to protein S-sulfhydration and S-nitrosylation. The schematic depicts enzymatic pathways that are responsible for endogenous H2S production, formation of low-molecular-weight and proteinaceous persulfides and the mitochondrial pathway for persulfide degradation. Notably, in addition to endogenous mammalian enzymes, sulfate-reducing bacteria (SRB) of the colon are major contributors to H2S generation in vivo. Abbreviations: CSE, cystathionine γ-lyase; CBS, cystathionine β-synthase ; MST, mercaptopyruvate sulfurtransferase; SQR, sulfide quinone reductase; ETHE1, persulfide dioxygenase; TST, thiosulfate sulfur transferase (a.k.a. rhodanese).