Table 1.
Demographics and biochemical profile of the patient cohort used for biomarker discovery
| |
Clinical group |
|
|||
|---|---|---|---|---|---|
| Variable | BTC | PSC | IAC | Benign other | Healthy |
| Number |
39 |
10 |
7 |
14 |
22 |
| Female: male |
15:24 |
3:7 |
0:7 |
9:5 |
7:15 |
| Age (yrs) |
69 (27–93) |
48 (22–76) |
64 (43–71) |
53 (35–47) |
60 (39–78) |
| Bilirubin (μmol/L) |
40 (8–616) |
17 (7–457) |
12 (5–40) |
8 (4–38) |
ND |
| CA19-9 (U/mL) |
295 (1–145528) |
17 (1–4119) |
15 (1–52) |
ND |
ND |
| CA19-9 >37 U/mL |
30/39 |
3/10 |
1/4 |
ND |
ND |
| CRP mg/L (N < 5) |
44.4 (1–171) |
9.9 (1–194.2) |
8.6 (5–35.7) |
ND |
ND |
| ALP (U/L) |
577 (138–1925) |
195 (98–514) |
229 (69–642) |
ND |
ND |
| IgG4 g/L (N < 1.3 g/L) |
ND |
ND |
1.5 (0.49-2.57) |
ND |
ND |
| WCC (x109/L) |
8.2 (3.3-14.8) |
6.0 (4.3-15.0)* |
7.6 (2.3-9.8) |
ND |
ND |
| Neutrophils (x109/L) | 5.9 (2.3-12.0) | 3.3 (2.8-13.4)* | 4.1 (0.7-5.4) | ND | ND |
BTC, biliary tract cancer; PSC, primary sclerosing cholangitis; IAC, IgG4-associated cholangitis. Benign other group comprises sphincter of Oddi dysfunction, stenosis of the Ampulla of Vater and chronic pancreatitis. CA19-9, carbohydrate antigen 19–9; CRP, C-reactive protein; ALP, alkaline phosphatase; IgG4, immunoglobulin G4; WCC, white cell count. Unless otherwise indicated, values indicate median (with range); ND, not determined; *WCC and neutrophil counts were available for only 6 of the 11 PSC patients.