The curve shows the probability of progression of MGUS to multiple myeloma, IgM lymphoma, primary amyloidosis, macroglobulinemia, chronic lymphocytic leukemia, or plasmacytoma (115 patients). The bars show 95% confidence levels. Modified from Kyle RA et al. N Engl J Med. 2002.[43] Copyright © 2002 by the Massachusetts Medical Society. All rights reserved. Used with permission.