Table 1.

Treatment schema

Regimen	Usual dosing schedule
Transplant candidates
Thalidomide/ dexamethasonea	Oral thalidomide 100–200mg on days 1–28 Oral dexamethasone 40mg on days 1, 8, 15, and 22, every 28 days Repeated every 4 weeks for four cycles as pretransplant induction therapy; or continued for up to 1 year if used as primary therapy
Lenalidomide/ dexamethasone	Oral lenalidomide 25mg on days 1–21, every 28 days Oral dexamethasone 40mg on days 1, 8, 15, and 22, every 28 days Repeated every 4 weeks for two cycles as pretransplant induction therapy; or continued until progression if used as primary therapy
Bortezomib/ dexamethasone	Intravenous bortezomib 1.3 mg/m2 on days 1, 4, 8, and 11 Oral dexamethasone 40mg on days 1–4, 9–12 Reduce dexamethasone to days 1–4 only after first two cycles Repeated every 3 weeks for 2–4 cycles as pretransplant induction therapy
Bortezomib/ thalidomide/ dexamethasonea	Intravenous bortezomib 1.3 mg/m2 on days 1, 4, 8, and 11 Oral thalidomide 200 mg, days 1–21 Dexamethasone 20mg on the day of and the day after bortezomib Repeated every 3 weeks for three cycles as pretransplant induction therapy
Bortezomib/pegylated liposomal doxorubicin/ dexamethasone	Intravenous bortezomib 1.3 mg/m2 on days 1, 4, 8, and 11 Pegylated liposomal doxorubicin 30 mg/m2 on day 4 Dexamethasone 40mg on days 1–11, and 15–18 for cycle 1 and days 1–4 for cycles 2–4
Cyclophosphamide/ thalidomide/ dexamethasone	Cyclophosphamide 500mg post-operative on days 1, 8 and 15 Thalidomide 100–200 mg/day Dexamethasone 40 mg/day post-operative on days 1–4, 12–15 every 3 weeks
Non-transplant candidates
Melphalan/prednisone/ thalidomideb	Oral melphalan 0.25 mg/kg on days 1–4 Oral prednisone 2mg/kg on days 1–4 Oral thalidomide 100–200mg on days 1–28 Repeated every 6 weeks for 12 cycles
Melphalan/prednisone/ bortezomib	Oral melphalan 9 mg/m2 on days 1–4 Oral prednisone 60 mg/m2 on days 1–4 Intravenous bortezomib 1.3 mg/m2 on days 1, 4, 8, 11, 22, 25, 29 and 32 Repeat every 42 days for four cycles followed by maintenance therapy Oral melphalan 9 mg/m2 on days 1–4 Oral prednisone 60 mg/m2 on days 1–4 Intravenous bortezomib 1.3 mg/m2 on days 1, 8, 15 and 22 Repeated every 35 days for five cycles
Melphalan/prednisone/ lenalidomide	Oral melphalan from 0.18 mg/kg on days 1–4 Oral prednisone 2mg/kg on days 1–4 Oral lenalidomide from 10mg on days 1–21 Repeated every 28 days for 9 monthly cycles

^aDexamethasone dose listed is lower than used in trial.

^bThalidomide dose listed is lower than used in trial.