Table 1.
Participant Characteristics (n=428).
| Variables | Summary Statistics |
|---|---|
| Baseline diagnosis, n(%) | |
| Normal | 181 (42.3%) |
| MCI | 247 (57.7%) |
| Gender, n(%) | |
| Male | 256 (59.8%) |
| Female | 172 (40.2%) |
| Baseline age (years), mean ± SD | 75.2 ± 6.4 |
| Years of education, mean ± SD | 15.9 ± 2.9 |
| BMI at 36 months, mean ± SD | 26.0 ± 4.1 (n=416) |
| BMI at 36 months, n(%) | (n=416) |
| Underweight | 5 (1.2%) |
| Normal | 172 (41.3%) |
| Overweight | 171 (41.1%) |
| Obese | 68 (16.3%) |
| APOE ε4 allele carriers, n(%) | 176 (41.1%) |
| History of Smoking, n(%) | 166 (38.8%) |
| Comorbidities at 36 Months, n(%) | |
| Diabetes | 37 (8.6%) |
| High Cholesterol | 309 (72.2%) |
| Atrial Fibrillation | 33 (7.7%) |
| Vascular disease | 60 (14.0%) |
| Depression | 93 (21.7%) |
| Medication Use at 36 Months, n(%) | |
| Blood pressure medication | 204 (47.7%) |
| Statin Medication | 191 (44.6%) |
| Cognitive Scores at 36 Months, mean ± sd (n) | |
| ADAS-COG | 17.0 ± 11.4 (n=402) |
| MMSE | 26.5 ± 4.4 (n=427) |
| CDR | 2.2 ± 2.8 (n=418) |
| Rey Auditory Verbal Learning Test | 32.4 ± 13.0 (n=423) |
| Digit Symbol | 40.0 ± 15.0 (n=419) |
| Executive Z-score | 0.16 ± 0.90 (n=403) |
| Trails B (sec) | 118.9 ± 77.8 (n=404) |
| Vegetable Fluency | 11.4 ± 5.2 (n=424) |
| Animal Fluency | 16.6 ± 6.5 (n=425) |
Mild cognitive impairment (MCI), body mass index in kg/m^2 (BMI), Clinical Dementia Rating Sum of Boxes (CDR), Mini-Mental Status Exam (MMSE), Modified Alzheimer's Disease Assessment Scale Cognitive Impairment (ADAS-COG) and Trail Making B (Trails B),. Underweight was defined as BMI ≤18.5, normal weight as BMI = 18.5–24.9, overweight as BMI = 25–29.9, and obese as BMI of 30 or greater.