Table 3.

Results from Final Analysis of Covariance Models with each 36 Month Cognitive Score collected at 36 months as the Outcome and Various Within-person Systolic Blood Pressure Summary Statistics Calculated using Measurements from Screening through 36 Months as Predictor Variables^*

Models		Cognitive Outcomes
		Modified ADAS-COG	MMSE	CDR	REY	Digit Symbol	Executive Z-score
1	Mean SBP	0.01 ± 0.03	−0.01 ± 0.01	−0.003 ± 0.008	−0.06 ± 0.03	−0.02 ± 0.03	−0.002 ± 0.002
		0.7738	0.5045	0.7463	0.0714	0.4704	0.3143
2	SD SBP	0.18 ± 0.07	−0.03 ± 0.03	0.05 ± 0.02	−0.23 ± 0.09	−0.12 ± 0.09	−0.019 ± 0.006
		0.0122	0.3597	0.0314	0.0069	0.1886	0.0033
3	CV SBP	0.25 ± 0.10	−0.04 ± 0.05	0.07 ± 0.03	−0.27 ± 0.12	−0.16 ± 0.12	−0.024 ± 0.009
		0.0110	0.4304	0.0229	0.0241	0.1860	0.0064
4	Max SBP	0.04 ± 0.02	−0.01 ± 0.01	0.01 ± 0.01	−0.06 ± 0.03	−0.04 ± 0.03	−0.004 ± 0.002
		0.0755	0.2378	0.3133	0.0309	0.1384	0.0492
5	SD SBP	0.19 ± 0.07	−0.03 ± 0.04	0.05 ± 0.02	−0.21 ± 0.09	−0.11 ± 0.09	−0.018 ± 0.006
	Mean SBP	0.0124	0.4371	0.0221	0.0188	0.2377	0.0054
		−0.01 ± 0.03	−0.01 ± 0.01	−0.01 ± 0.01	−0.04 ± 0.03	−0.02 ± 0.04	−0.001 ± 0.002
		0.7850	0.6456	0.3956	0.2220	0.6628	0.7189

Clinical Dementia Rating Sum of Boxes (CDR), Mini-Mental Status Exam (MMSE), the Modified Alzheimer's Disease Assessment Scale Cognitive Impairment (ADAS-COG), executive function (Executive z-score), Rey Auditory Verbal Learning Test (Rey), systolic blood pressure (SBP), standard deviation of SBP (SD SBP), coefficient of variation in SBP (CV SBP), and maximum SBP (Max SBP). The analysis in model 5 includes both mean SBP and SBP variance measures.

^*Results shown are Parameter Estimate ± Standard Error on the first line and p-value on the second line. All models are adjusted for baseline scores, age, years of education, gender, and presence of APOE ε4 allele, in addition to vascular disease, BMI, and depression at 36 months