Figure 6. Low level of glucose-stimulated α-ketoglutarate and/or malate and increased citrate in INS-1 832/13-derived cell lines with knocked down mitochondrial NAD-IDH (IDH3) and/or mitochondrial NADP-IDH (IDH2).

Cells were incubated with 11.1 mM glucose or glutamine (10 mM)-plus-BCH (10 mM) for 30 min. Results are the mean ± SE from five separate experiments. ^ap < 0.001, ^bp < 0.01 and ^cp < 0.05 vs HygC control same condition.