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. 2012 Oct 29;16(11):2647–2654. doi: 10.1111/j.1582-4934.2012.01578.x

Table 2.

Genes altered via miR-29ab1 knockdown during CCl4 treatment

Symbol Gene description Fold change
Genes decreased via miR-29ab1 knockdown
 h19 H19 foetal liver mRNA −17.33
 ngp Neutrophilic granule protein −10.30
 retnlg Resistin like gamma −9.28
 umod Uromodulin −6.45
 lgals3 Lectin galactose binding soluble 3 −5.95
 camp Cathelicidin antimicrobial peptide −5.46
 gpnmb Glycoprotein (transmembrane) nmb −5.24
 cd24a CD24a antigen −5.06
 mmp8 Matrix metallopeptidase 8 −4.60
 sirpb1 Signal-regulatory protein beta 1 −4.51
Genes increased via miR-29ab1 knockdown
 retsat Retinol saturase (all trans retinol 13 14 reductase) 8.81
 cyp4a12b Cytochrome P450 family 4 subfamily a polypeptide 12B 6.37
 cyp4a12a Cytochrome P450 family 4 subfamily a polypeptide 12a 5.93
 hsd3b5 Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase 5 3.68
 csad Cysteine sulphinic acid decarboxylase 3.59
 bcl6 B-cell leukaemia/lymphoma 6 3.35
 2810007j24rik RIKEN cDNA 2810007J24 gene 3.30
 slco1a1 Solute carrier organic anion transporter family member 1a1 3.21
 glul Glutamate-ammonia ligase (glutamine synthetase) 2.97
 camk1d Calcium/calmodulin-dependent protein kinase ID 2.95

Whole genome gene expression was analysed in control mouse without treatment, control and miR29ab1 knockout mouse with CCl4 treatment. The expression of total 763 genes were increased by CCl4 administration in control mouse, and of these, 204 genes decreased in expression in miR29ab1 knockout mouse receiving CCl4 compared with control mouse receiving CCl4. The expression of total 369 genes were decreased by CCl4 in control mouse, and of these, 24 genes increased in expression in miR29ab1 knockout mouse receiving CCl4 compared with control mouse receiving CCl4. The Top 10 genes with altered expression are listed.