Table 2.
Symbol | Gene description | Fold change |
---|---|---|
Genes decreased via miR-29ab1 knockdown | ||
h19 | H19 foetal liver mRNA | −17.33 |
ngp | Neutrophilic granule protein | −10.30 |
retnlg | Resistin like gamma | −9.28 |
umod | Uromodulin | −6.45 |
lgals3 | Lectin galactose binding soluble 3 | −5.95 |
camp | Cathelicidin antimicrobial peptide | −5.46 |
gpnmb | Glycoprotein (transmembrane) nmb | −5.24 |
cd24a | CD24a antigen | −5.06 |
mmp8 | Matrix metallopeptidase 8 | −4.60 |
sirpb1 | Signal-regulatory protein beta 1 | −4.51 |
Genes increased via miR-29ab1 knockdown | ||
retsat | Retinol saturase (all trans retinol 13 14 reductase) | 8.81 |
cyp4a12b | Cytochrome P450 family 4 subfamily a polypeptide 12B | 6.37 |
cyp4a12a | Cytochrome P450 family 4 subfamily a polypeptide 12a | 5.93 |
hsd3b5 | Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase 5 | 3.68 |
csad | Cysteine sulphinic acid decarboxylase | 3.59 |
bcl6 | B-cell leukaemia/lymphoma 6 | 3.35 |
2810007j24rik | RIKEN cDNA 2810007J24 gene | 3.30 |
slco1a1 | Solute carrier organic anion transporter family member 1a1 | 3.21 |
glul | Glutamate-ammonia ligase (glutamine synthetase) | 2.97 |
camk1d | Calcium/calmodulin-dependent protein kinase ID | 2.95 |
Whole genome gene expression was analysed in control mouse without treatment, control and miR29ab1 knockout mouse with CCl4 treatment. The expression of total 763 genes were increased by CCl4 administration in control mouse, and of these, 204 genes decreased in expression in miR29ab1 knockout mouse receiving CCl4 compared with control mouse receiving CCl4. The expression of total 369 genes were decreased by CCl4 in control mouse, and of these, 24 genes increased in expression in miR29ab1 knockout mouse receiving CCl4 compared with control mouse receiving CCl4. The Top 10 genes with altered expression are listed.