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. Author manuscript; available in PMC: 2015 Jan 23.
Published in final edited form as: Mol Cell. 2014 Jan 23;53(2):344–350. doi: 10.1016/j.molcel.2013.12.024

Figure 3.

Figure 3

Yeast system to study the function of Hsp90 dimers of defined composition. (A) Under selective conditions, the growth of the engineered strain is strictly dependent on the function of A/B Hsp90 heterodimers: full-length heterodimers support robust growth but known null heterodimers lacking the N and M domains in one subunit do not support growth. Control cells grown without FOA all support growth indicating that none of the constructs are toxic. (B) Growth rates in liquid culture parallel growth observed on plates. See also Figure S2.