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. 2013 Oct 24;209(5):749–753. doi: 10.1093/infdis/jit572

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© The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 2. — Macrophages harboring both CARD8 C10X and NLRP3 Q705K polymorphisms display increased growth control of M. tuberculosis. Human monocyte–derived macrophages from healthy blood donors (n = 43) were infected with H37Rv-lux at multiplicity of infection 10 for 1 hour before luminescence was measured (ie, on day 0). Forty-eight hours after infection (ie, on day 2), luminescence was measured again. Bacterial growth was calculated as the day 2 value divided by the day 0 value. The same donors were genotyped for 2 polymorphisms (Q705K and C10X), and the mean bacterial growth was compared between different groups. The figure shows the comparison between both heterozygous and homozygous individuals for CARD8 C10X (n = 19) and individuals with none of the studied polymorphisms (wild type; n = 18; A), individuals heterozygous for NLRP3 Q705K (n = 3) and wild-type individuals (B), and individuals heterozygous for CARD8 C10X plus NLRP3 Q705K (n = 3) and the wild-type population (C). The Student's t test was used for comparison in all panels. *P < .05, **P < .01.