Skip to main content
. 2014 Jan 16;209(5):703–710. doi: 10.1093/infdis/jit635

Figure 4.

Figure 4.

Model proposed to explain differing impact of preexisting nevirapine (NVP)–resistant mutations in trial 1 (women with single-dose NVP [sdNVP] exposure) and trial 2 (women without sdNVP exposure). The greater area under the curve shaded in gray represents the greater expansion of mutant populations under drug selective pressure in women with sdNVP exposure providing more opportunity for linkage of other resistance mutations during ongoing cycles of replication. The smaller area under the curve shown in dark gray represents the smaller proportions of mutations occurring stochastically in women without sdNVP exposure, providing fewer opportunities for linkage to other resistance mutations on the same genome. Abbreviations: cART, combination antiretroviral therapy; NRTI, nucleoside reverse transcriptase inhibitor.