Table 2.
Comparison of Associations from Multivariate Logistic Models of incident PD* and Baseline Smoking Characteristics Using Current Case Ascertainment Method and Original Algorithm in the Cardiovascular Health Study, 1989-2006.
| Current Adjudication |
Original Algorithm† |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Crude Distribution | Adjusted** | Adjusted‡ | ||||||||
|
|
||||||||||
| PD | no PD | |||||||||
|
|
||||||||||
| Characteristic | n=165 | (%) | n=5679 | (%) | OR** | 95% CI | P-valuea | OR‡ | 95% CI | P-valuea |
| Smoking Status | 0.009 | 0.025 | ||||||||
| Never | 80 | (48.5) | 2634 | (46.4) | 1.00 | Reference | 1.00 | Reference | ||
| Former | 74 | (44.9) | 2297 | (40.5) | 0.83 | (0.59, 1.16) | 0.86 | (0.61, 1.12) | ||
| Current | 11 | (6.7) | 742 | (13.1) | 0.42 | (0.22, 0.79) | 0.46 | (0.24, 0.88) | ||
| Years since quitting | 0.005 | 0.015 | ||||||||
| Never smoker | 80 | (49.4) | 2634 | (47.0) | 1.00 | Reference | 1.00 | Reference | ||
| ≥ 30 years | 23 | (14.2) | 604 | (10.8) | 0.99 | (0.61, 1.61) | 1.01 | (0.61, 1.68) | ||
| 20-29 | 21 | (13.0) | 560 | (10.0) | 0.96 | (0.58, 1.58) | 0.92 | (0.54, 1.58) | ||
| 10-19 | 12 | (7.4) | 585 | (10.4) | 0.54 | (0.29, 1.00) | 0.76 | (0.43, 1.34) | ||
| >1-10 | 15 | (9.2) | 477 | (8.5) | 0.84 | (0.48, 1.48) | 0.40 | (0.43, 1.40) | ||
| Current smoker | 11 | (6.8) | 742 | (13.3) | 0.42 | (0.22, 0.79) | 0.46 | (0.24, 0.88) | ||
| Cigarettes per day | 0.019 | 0.041 | ||||||||
| Never smoker | 80 | (50.3) | 2634 | (47.5) | 1.00 | Reference | 1.00 | Reference | ||
| <10 | 16 | (10.1) | 624 | (11.2) | 0.80 | (0.46, 1.38) | 0.90 | (0.52, 1.54) | ||
| 10-19 | 23 | (14.5) | 802 | (14.4) | 0.81 | (0.51, 1.31) | 0.94 | (0.59, 1.51) | ||
| 20-28 | 29 | (18.2) | 935 | (16.5) | 0.76 | (0.48, 1.19) | 0.62 | (0.37, 1.03) | ||
| ≥ 29 | 11 | (6.9) | 559 | (10.0) | 0.45 | (0.51, 1.31) | 0.61 | (0.33, 1.14) | ||
| Total pack-years | 0.005 | 0.032 | ||||||||
| Never smoker | 80 | (50.6) | 2634 | (48.0) | 1.00 | Reference | 1.00 | Reference | ||
| 1st quartile(0-13) | 29 | (18.4) | 829 | (15.1) | 0.99 | (0.64, 1.54) | 0.82 | (0.57, 1.50) | ||
| 2nd quartile (14-27) | 17 | (10.8) | 643 | (11.7) | 0.72 | (0.42, 1.24) | 0.95 | (0.58, 1.56) | ||
| 3rd quartile (28-49) | 13 | (8.3) | 505 | (9.2) | 0.65 | (0.36, 1.20) | 0.72 | (0.42, 1.23) | ||
| 4th quartile (> 50) | 19 | (12.0) | 880 | (16.0) | 0.51 | (0.30, 0.85) | 0.53 | (0.29, 0.96) | ||
*
PD defined as Probable PD by adjudication
**
Adjusted for age, sex, African American race, and education
†
Incident PD = 154, as described in reference 2;
‡
Adjusted for age, sex, African American race, and education.
a
Test for linear trend