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. 2014 Feb 15;25(4):481–494. doi: 10.1091/mbc.E13-10-0571

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© 2014 Gaffaney et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 8: — Expression of Doc2-C2A_clmB_clm enhances spontaneous release in wt hippocampal neurons. (A) Representative traces of mEPSCs recorded from wt neurons with and without expression of Doc2β-wt or Doc2β-C2A_clmB_clm. (B) The frequency of mEPSCs (control: 1.9 ± 0.3 Hz, n = 42) was not significantly increased by expression Doc2β-wt (2.7 ± 0.3 pC, n = 42) but was significantly increased by Doc2β-C2A_clmB_clm (4.1 ± 0.4 pC, n = 46). (C) mEPSC amplitude was not affected by expression of Doc2β-wt or Doc2β-C2A_clmB_clm. Data are represented as mean ± SEM. *p < 0.05, ***p < 0.001, Student's t test. The number of cells, n, is indicated in the bar graphs; in all cases recordings were obtained using neurons from four or more independent litters of mice.