Table 1. The distribution of oncogenic mutations and SNPs on PDB structures of target proteins in IL-1 pathway.
| Protein | PDB Code | COSMIC | COSMIC Surface | LS-SNP | LS-SNP Surface | Total Residues | Surface Residues |
| ATF2, CREB | 1t2kD | 1 | 0 | 1 | 1 | 61 | 61 |
| ATF2, CREB | 4h36B | 0 | 0 | 0 | 0 | 8 | 8 |
| c-Fos, FOS | 1fosE | 4 | 4 | 2 | 2 | 60 | 60 |
| c-Jun, JUN | 1jnmA, 1fosF | 4 | 4 | 1 | 1 | 57 | 57 |
| c-Myc, MYC | 1nkpA | 8 | 7 | 0 | 0 | 88 | 81 |
| ELK1 | 1duxC | 7 | 5 | 0 | 0 | 88 | 61 |
| ERK1, MAPK3 | 2zoqA | 14 | 10 | 11 | 9 | 351 | 209 |
| ERK2,MAPK2 | 1wzyA, 3teiA, 4fv4A, 4fv7A, 1tvoA, 4fv0A, 2y9qA | 26 | 17 | 3 | 3 | 365 | 199 |
| histone H3.3 | 4hgaB | 0 | 0 | 6 | 6 | 93 | 85 |
| HSP27 | 3q9qA | 2 | 1 | 9 | 9 | 79 | 67 |
| NFKBIA | 1nfiE, 1iknD | 0 | 0 | 8 | 6 | 215 | 142 |
| NFKBIB | 1oy3D | 0 | 0 | 0 | 0 | 220 | 130 |
| IKBKA, CHUK, IKBKB | 3brtA, 3brvA | 0 | 0 | 8 | 8 | 39 | 39 |
| IKBKG | 3brvB, 3brtB | 0 | 0 | 1 | 1 | 62 | 61 |
| IL1A | 2l5xA | 6 | 3 | 11 | 8 | 151 | 102 |
| IL1R1 | 4depB | 18 | 13 | 29 | 21 | 296 | 216 |
| IL1RAP | 4depC | 16 | 13 | 14 | 9 | 288 | 201 |
| IRAK2 | 3mopK | 3 | 1 | 11 | 5 | 93 | 65 |
| IRAK4 | 3mopG | 2 | 2 | 7 | 5 | 107 | 76 |
| IRF7 | 2o61A | 0 | 0 | 0 | 0 | 498 | 351 |
| JNK1, MAPK8 | 3o17A, 1ukhA, 3eljA | 30 | 18 | 8 | 7 | 366 | 213 |
| JNK2, MAPK9 | 3e7oA, 3npcA | 30 | 18 | 9 | 8 | 357 | 211 |
| JNK3 | 3fv8A, 2zduA, 2r9sA, 4h36 | 2 | 1 | 8 | 4 | 356 | 203 |
| MAPKAPK2 | 2jboA, 2onlC | 22 | 16 | 13 | 11 | 317 | 211 |
| MAPK14 | 1kv1A, 2bajA, 3odyX, 3queA, 1w82A, 2y8oA, 2onlA | 0 | 0 | 30 | 24 | 351 | 211 |
| MAPK11 | 3gc9A, 3gp0A, 3gc8A | 0 | 0 | 26 | 21 | 347 | 213 |
| MEKK3, MAP3K3 | 2pphA, 2jrhA, 2c60A | 6 | 4 | 3 | 3 | 93 | 76 |
| MKK1, MAP2K1 | 2p55A | 31 | 17 | 6 | 6 | 289 | 181 |
| MKK2, MAP2K2 | 1s9iA | 17 | 12 | 12 | 10 | 303 | 182 |
| MKK4, MAP2K4 | 3aloA, 3alnA, 3vutA | 56 | 40 | 6 | 4 | 289 | 190 |
| MKK6, MAP2K6 | 3vn9A, 3fmeA | 25 | 19 | 7 | 6 | 291 | 174 |
| MKK6, MAP2K6 | 2y8oB | 0 | 0 | 0 | 0 | 8 | 8 |
| MKK7, MAP2K7 | 2dylA | 29 | 22 | 6 | 3 | 272 | 172 |
| MNK1, MKNK1 | 2hw6A | 0 | 0 | 16 | 10 | 242 | 145 |
| MNK1, MKNK1 | 2y9qB | 0 | 0 | 0 | 0 | 17 | 17 |
| MNK2, MKNK2 | 2ac3A | 0 | 0 | 9 | 7 | 277 | 191 |
| MSK1, RPS6KA5 | 3kn5A, 3kn6A | 23 | 12 | 14 | 10 | 282 | 174 |
| MSK1, RPS6KA5 | 1vzoA | 20 | 14 | 15 | 12 | 324 | 188 |
| MYD88 | 2js7A, 2z5vA | 22 | 14 | 0 | 0 | 160 | 106 |
| MYD88 | 3mopA | 7 | 7 | 0 | 0 | 105 | 74 |
| NF-kBp105 | 3gutB | 0 | 0 | 9 | 7 | 312 | 198 |
| NFKB1 | 1svcP, 1nfiB | 0 | 0 | 8 | 6 | 311 | 198 |
| NFKB3, RELA | 1nfiA, 3gutA | 0 | 0 | 12 | 11 | 295 | 208 |
| NIK, MAP3K14 | 4g3dA, 4dn5A | 14 | 7 | 5 | 4 | 331 | 194 |
| TAB1 | 2j4oA | 25 | 18 | 21 | 16 | 355 | 207 |
| TAK1 | 2yiyA, 2evaA | 21 | 15 | 8 | 4 | 295 | 181 |
| TOLLIP | 1wglA | 3 | 3 | 5 | 3 | 59 | 51 |
| TRAF6 | 1lb4A, 1lb5A, 1lb6A, | 12 | 11 | 3 | 2 | 155 | 112 |
| TRAF6 | 3hcsA, 3hctA, 2eciA | 13 | 11 | 9 | 7 | 157 | 119 |
| IL1B | 4depA | 16 | 12 | 4 | 2 | 151 | 100 |
| IL1R1 (model) | - | 0 | 0 | 0 | 0 | 157 | 106 |
| IL1RAP (model) | - | 0 | 0 | 0 | 0 | 145 | 96 |
| TOTAL | 535 | 371 | 394 | 302 | 10988 | 7181 |