Table 3. t-test for COSMIC mutations mapped onto the interface region including the nearby residues.

	COSMIC mutations on interface region+nearby residues/total interface size with nearby residues	COSMIC mutations on noninterface region/total noninterface size
Mean	0.039	0.061
Variance	0.001	0.002
Observations	77	77
Pooled Variance	0.002
Hypothesized Mean Difference	0
df	152
t Stat	−3.397
P(T< = t) one-tail	0.0004
t Critical one-tail	1.655
P(T< = t) two-tail	0.0009
t Critical two-tail	1.976