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. 2014 Feb 13;10(2):e1003466. doi: 10.1371/journal.pcbi.1003466

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© 2014 Lesaint et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Data are expressed as mean S.E.M. (A,B) Reproduction of Flagel et al. [14] experimental results (Figure 4 a,d). Effects of flupentixol on the probability to approach the lever for STs (A) and the magazine for GTs (B) during lever presentation. (C,D) Simulation of the same procedure (squares) with the model. Simulated groups of rats are defined as in Figure 5. (C) By flattening the softmax temperature and reducing the RPEs of the Feature-Model-Free system, to mimic the possible effect of flupentixol, the model can reproduce the blocked acquisition of sign-tracking in STs (red), engaging less the lever relatively to a saline-injected control group (white). (D) Similarly, the model reproduces that goal-tracking was learned but its expression was blocked. Under flupentixol (first 7 sessions), GTs (blue) did not express goal-tracking, but on a flupentixol-free control test ( session) their engagement with the magazine was almost identical to the engagement of a saline-injected control group (white).

Inline graphic — Data are expressed as mean S.E.M. (A,B) Reproduction of Flagel et al. [14] experimental results (Figure 4 a,d). Effects of flupentixol on the probability to approach the lever for STs (A) and the magazine for GTs (B) during lever presentation. (C,D) Simulation of the same procedure (squares) with the model. Simulated groups of rats are defined as in Figure 5. (C) By flattening the softmax temperature and reducing the RPEs of the Feature-Model-Free system, to mimic the possible effect of flupentixol, the model can reproduce the blocked acquisition of sign-tracking in STs (red), engaging less the lever relatively to a saline-injected control group (white). (D) Similarly, the model reproduces that goal-tracking was learned but its expression was blocked. Under flupentixol (first 7 sessions), GTs (blue) did not express goal-tracking, but on a flupentixol-free control test ( session) their engagement with the magazine was almost identical to the engagement of a saline-injected control group (white).