Figure 3. Allelic variation limited to chr19 influences the timing of onset of cutaneous phenotypes of JEB.

A, Average ear and tail scores, and B, 10 week old tail tension test values comparing B6 mice (most susceptible) with B6.chr19^PWD consomic (most resistant), B6.chr19^A/J consomic, B6.chr19^129S1 congenic, and B6 × B6.chr19^B6/PWD heterozygous male mice (intermediate resistance). A, N = 2 to 50 mice per timepoint. *, P≤0.05; ***; ≤0.001; ****, ≤0.0001; NS, >0.05. C, Representative images of ears and tails from 23 week old male B6 and B6.chr19^PWD consomic mice. All mice are Lamc2^jeb/jeb.