Pharmacodynamic (cGMP) analysis after acute administration of SCH-51866 in male R6/2 mice.

(A) Quantification of SCH-51866 concentration in extracellular dialysate after po acute administration; dialysate levels shown are not adjusted for recovery factor, which on average was 56%; (B) Quantification of cGMP elevation measured in extracellular dialysate after acute po administration; (C) Correlation of AUC evaluation of SCH-51866 and cGMP elevation in extracellular dialysate shows a dose-proportional increase in cGMP in response to increasing concentration of SCH-51866. Elevation in cGMP was significant over baseline for both 10 and 30 mg/kg dose groups, but not the 3 mg/kg dose group.