Evaluation of HTT aggregate load, and markers of transcriptional dysregulation, after chronic administration of SCH-51866 in R6/2 animals.

A) Analysis of cortical and hippocampal aggregated HTT levels as measured using the Seprion ligand in R6/2 animals dosed with vehicle or SCH-51866. (B-C) Analysis of specified gene expression changes in R6/2s vs control littermates and in R6/2s treated chronically with SCH-51866 in B) cortex, C) striatum, and D) cerebellum. The drug had no effects on the dysregulation of these genes. Bdnf = brain derived neurotrophic factor, promoter transcripts 1, 4 and 5 and coding region (b); Penk1 = preproenkephalin; Cnr1 = cannabinoid receptor 1; Drd2 = dopamine receptor 2; Darpp32 = dopamine and cAMP regulated neuronal phosphoprotein; Kcnk2 = potassium channel, subfamily K member 2; Nr4a2 = nuclear receptor subfamily 4 group A member 2; Igfbp5 = insulin-like growth factor binding protein; Pcp4 = Purkinje cell protein 4; Uchl1 = ubiquitin carboxy-terminal hydrolase L1