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. 2014 Feb 13;6:ecurrents.hd.3304e87e460b4bb0dc519a29f4deccca. [Version 1] doi: 10.1371/currents.hd.3304e87e460b4bb0dc519a29f4deccca

Evaluation of SCH-51866 in acute hippocampal slices.

Evaluation of SCH-51866 in acute hippocampal slices.

(A) Basal synaptic transmission is elevated in R6/2 compared to WT. SCH-51866 has no significant effect on R6/2 input/ouput (I/O) parameters; (B) SCH-51866 restored R6/2 paired-pulse facilitation (PPF) to WT levels; (C) SCH-51866 did not restore the deficit in R6/2 long-term potentiation (LTP). Significance is denoted by asterisks (p< 0.0001 = ****, p < 0.01=**)