Table 4 - Summary of the survival study in R6/2 mice.
| Vehicle (p.o., BID) (30% Propylene Glycol, 20% Solutol HS15, 50% 50nM Citrate) |
10 mg/kg (p.o., BID) SCH-51866 |
30 mg/kg (p.o., BID) SCH-51866 |
|
|---|---|---|---|
| Mean (±SEM) / Medial Survival Time (days) | 115 (±5) / 106 | 115 (±7) / 110 | 122 (±5) / 121 |
| Log-rank (Peto) Test | Chi-square for equiv. of death rates p=0.555 Hazard ratio vs. other groups: vs. 10 mg/kg = 1.340 vs. 30 mg/kg = 1.325 |
Chi-square for equiv. of death rates p=0.555 Hazard ratio vs. other groups: vs. Vehicle = 1.340 vs. 30 mg/kg = 0.988 |
Chi-square for equiv. of death rates p=0.555 Hazard ratio vs. other groups: vs. Vehicle = 1.325 vs. 10 mg/kg = 0.988 |
| Generalized Wilcoxon (Peto-Prentice) Test | Chi-square for equiv. of death rates p=0.543 | Chi-square for equiv. of death rates p=0.543 | Chi-square for equiv. of death rates p=0.543 |