Table 1 - Selectivity Profile of SCH-51866 against a PDE 1-11 panel.

NI, no inhibition noted at concentrations tested (up to 10 µM at Cerep and up to 100 µM at Scottish Biomedical)

* Extrapolated value

Enzyme	SCH-51866 IC50(µM)
PDE1A3 (cAMP)	0.07
PDE2A3	1.32
PDE3 Cat	17.27*
PDE4 Cat	>100
PDE5 Cat	2.84
PDE6AB	NI
PDE7A1	>100
PDE8A1	NI
PDE9A2	51.35*
PDE10A1 (cAMP)	16.03*
PDE11A1 (cAMP)	21.89*