Table 2 - PK analysis of SCH-51866 in mice following oral (po), subcutaneous (sc) or intravenous (iv) administration.
1 Values were not calculated since there were not enough points in the elimination phase.
NA: Not applicable PK parameters due to route and/or matrix.
NC: Not calculated due to insufficient data points to define the corresponding PK parameter.
| PK Parameters | Units | Plasma | Brain | ||
|---|---|---|---|---|---|
| IV 5.0 (mg eq./kg) |
IV 5.0 (mg eq./kg) |
IV 5.0 (mg eq./kg) |
PO 10.0 (mg eq./kg) |
||
| AUC(0-last) | nM eq.·hr | 7310 | 8960 | 8180 | 2200 |
| AUC(0-inf) | nM eq.·hr | 7350 | 8970 | 8230 | NC |
| Bioavailability (F) | % | NA | 61.0 | NA | NA |
| Observed Cmax | nM eq. | NA | 2420 | 3560 | 475 |
| Observed Tmax | hr | NA | 1 | 0.5 | 2 |
| Plasma Clearance (CLp) | L/hr/kg | 1.75 | NA | NA | NA |
| Volume of Distribution at Steady State (Vdss) | L/kg | 4.48 | NA | NA | NA |
| Mean Residence Time (MRT) | hr | 2.57 | NA | NA | NA |
| Half-life (t1/2) | hr | 3.87 | 2.49 | 1.08 | NC1 |
| Half-life Regression Time Points | hr | 4, 8, 24 | 4, 8, 24 | 0.5, 2, 8 | NA |