Skip to main content
. 2014 Feb 13;9(2):e88393. doi: 10.1371/journal.pone.0088393

Figure 4. Effect of miR-141 on growth and invasion of HCC cell in vitro.

Figure 4

(A) MiR-141 mRNA expression levels in M3 transfectant clones and knockdown cell relative to control. (B) Up-regulation of miR-141 in HCCLM3 cells reduced inhibited cell proliferation, while inhibition of miR-141 expression in MHCC97L cells increased cells growth cell compared with the controls. (C) Representative images of Wound-healing assay. The wound healing rate in HCCLM3 cells transfected with miR-141 overexpressed lentivirus was significantly decreased, while accelerated in MHCC97L cells transfected with miR-141 inhibitor. (D) Representative images (left) and quantification (right) of the Transwell invasion assay. The number of invaded cells in the HCCLM3 cells was significantly decreased, while the number of invaded cells in the MHCC97L cells was significantly increased compared with control. Data is presented as the mean ± SEM; P values were calculated using the Student’s t-test. *P<0.05, **P<0.01.