Table 4. Correlation between WMH volumes and Digit Span Forward score according to COMT Val158Met genotyping.

	Digit Span Forward
	Met/Met		Met/Val		Val/Val
Anatomical Regions	Correlation (r)	p-value	Correlation (r)	p-value	Correlation (r)	p-value
Frontal Lobe	−0.570	0.001*	−0.128	0.159	0.035	0.671
Temporal Lobe	−0.500	0.003*	−0.033	0.715	0.063	0.453
Occipital Lobe	−0.408	0.019	0.036	0.693	0.046	0.580
Parietal Lobe	−0.366	0.036	−0.063	0.490	0.153	0.065
Limbic Lobe	−0.502	0.003*	−0.049	0.591	0.086	0.305
Subcortical Regions	−0.508	0.003*	−0.016	0.857	0.013	0.877
Cerebellar Region	0.091	0.616	0.000	0.997	0.089	0.284
Midbrain	−0.240	0.179	0.099	0.277	0.148	0.074
Medulla	−0.056	0.758	−0.016	0.865	−0.113	0.175
Whole brain	−0.547	0.001*	−0.069	0.445	0.061	0.466

Abbreviation: WMH: white matter hyperintensities.

Partial correlation analysis was performed controlling age, sex, years of education, and total intracranial volume as nuisance variable. All of the p-values showed in this table were unadjusted p-values.

*Bonferroni-corrected P<.05.