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. 2014 Feb 13;9(2):e88167. doi: 10.1371/journal.pone.0088167

Figure 7. The dose response curves and probability distribution of the output protein in the 3-layer cascades (denoted by Inline graphic) as a function of inducing signal Inline graphic, 1-layer in (A), 2-layer (B) and 3-layer (C).

Figure 7

The probability distribution can be directly obtained from Eq. (15) after normalization. The Hill coefficient for each cascade is fitted as 2.00, 3.15 and 4.08 respectively.