Figure 3. Presence of WT cells rescues IL-7Rα^449F/449F FO-MZ phenotype.

Irradiated Rag1^−/− mice were injected with (A) WT (n = 3) or IL-7Rα^449F/449F (n = 3) bone marrow alone or (B) a 9∶1 mixture of WT (n = 3) or IL-7Rα^449F/449F (n = 4) to B6.SJL bone marrow or and left for eight weeks to reconstitute. The proportion of CD45.1⁺ (BoyJ) and CD45.2⁺ (either WT or IL-7Rα^449F/449F) B220⁺CD21⁺ cells are shown, with the FO (CD21⁺CD23⁺) and MZ (CD21^hiCD23^lo) populations. The MZ/FO ratio is then shown (C) from the CD45.1⁺ and CD45.2⁺ populations. Experiments were repeated with at least three separate sets of chimeras, with similar results.