Table 1.
Comparison of patient and tumor characteristics among unimodal and bimodal therapy as well as for patients with ERBT only and surgery only
| Overall | Unimodal therapy | Bimodal therapy | p-value | ERBT only | Surgery only | p-value | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| Number of patients | 3,295 | 2,021 (61.3) | 1,274 (38.7) | 1,325 (65.6) | 696 (34.4) | ||
|
| |||||||
| Age, (years: mean, standard deviation) | 65.1 (11.0) | 68.0 (10.8) | 60.7 (9.8) | <0.001 | 68.7 (10.7) | 66.6 (10.8) | 0.73 |
| ≤65 | 1,643 (49.9) | 782 (38.7) | 861 (67.6) | <0.001 | 472 (35.6) | 310 (44.5) | <0.001 |
| >65 | 1,652 (50.1) | 1,239 (61.3) | 413 (32.4) | 853 (64.4) | 386 (55.5) | ||
|
| |||||||
| Female | 622 (18.9) | 436 (21.6) | 186 (14.6) | <0.001 | 287 (21.7) | 149 (21.4) | 0.90 |
|
| |||||||
| Race | |||||||
| White | 2,862 (86.9) | 1,705 (84.4) | 1,157 (90.8) | <0.001 | 1,092 (82.4) | 613 (88.1) | 0.001 |
| African-American | 257 (7.8) | 194 (9.6) | 63 (5.0) | 149 (11.3) | 45 (6.5) | ||
| Other/Unknown | 176 (5.3) | 122 (6.0) | 54 (4.2) | 84 (6.3) | 38 (5.5) | ||
|
| |||||||
| Ethnicity | |||||||
| Hispanic | 174 (5.3) | 120 (5.9) | 54 (4.2) | 0.03 | 1,241 (93.7) | 660 (94.8) | 0.29 |
| Non-Hispanic | 3,121 (94.7) | 1,901 (94.1) | 1,220 (95.8) | 84 (6.3) | 36 (5.2) | ||
|
| |||||||
| Marital Status | |||||||
| Married | 2,179 (66.1) | 1,263 (62.5) | 916 (71.9) | <0.001 | 817 (61.7) | 446 (64.1) | 0.29 |
| Other | 1,116 (33.9) | 758 (37.5) | 358 (28.1) | 508 (38.3) | 250 (35.9) | ||
|
| |||||||
| Tumor location | |||||||
| Mid esophagus | 779 (23.6) | 577 (28.6) | 202 (15.9) | <0.001 | 450 (34.0) | 127 (18.3) | <0.001 |
| Lower esophagus | 2,516 (76.4) | 1,444 (71.5) | 1,072 (84.1) | 875 (66.0) | 569 (81.2) | ||
|
| |||||||
| Histology | |||||||
| Adenocarcinoma | 2,221 (67.4) | 1,217 (60.2) | 1,004 (78.8) | <0.001 | 738 (55.7) | 479 (68.8) | <0.001 |
| Squamous cell carcinoma | 1,074 (32.6) | 804 (39.8) | 270 (21.2) | 587 (44.3) | 217 (31.2) | ||
|
| |||||||
| Primary tumor (T) | |||||||
| T1 | 454 (13.8) | 328 (16.2) | 126 (9.9) | <0.001 | 219 (16.5) | 109 (15.7) | <0.001 |
| T2 | 599 (18.2) | 349 (17.3) | 250 (19.6) | 212 (16.0) | 137 (19.7) | ||
| T3 | 2,069 (62.8) | 1,210 (59.9) | 859 (67.4) | 776 (58.6) | 434 (62.4) | ||
| T1/T2 | 173 (5.3) | 134 (6.6) | 39 (3.1) | 118 (8.9) | 16 (2.3) | ||
|
| |||||||
| Tumor stage | |||||||
| IIB | 1,226 (37.2) | 811 (40.1) | 415 (32.6) | <0.001 | 549 (41.4) | 262 (37.6) | 0.10 |
| III | 2,069 (62.8) | 1,210 (59.9) | 859 (67.4) | 776 (58.6) | 434 (62.4) | ||
|
| |||||||
| Tumor grade | |||||||
| G1/2 (well/moderate) | 1,308 (39.7) | 808 (40.0) | 500 (39.3) | 0.11 | 538 (40.6) | 270 (38.8) | <0.001 |
| G3/4 (poor/undifferentiated) | 1,618 (49.1) | 953 (47.2) | 665 (52.2) | 555 (41.9) | 398 (57.2) | ||
| Unknown | 369 (11.2) | 260 (12.9) | 109 (8.6) | 232 (17.5) | 28 (4.0) | ||
|
| |||||||
| Cause of death | |||||||
| Alive | 1,081 (32.8) | 524 (25.9) | 557 (43.7) | <0.001 | 336 (25.4) | 188 (27.0) | 0.69 |
| Esophagus | 1,781 (54.1) | 1,191 (58.9) | 590 (46.3) | 789 (59.6) | 402 (57.8) | ||
| Other cause of death | 433 (13.1) | 306 (15.1) | 127 (10.0) | 200 (15.1) | 106 (15.2) | ||
|
| |||||||
| Number of primary tumors | |||||||
| 1 | 2,727 (82.8) | 1,458 (80.1) | 1,070 (86.8) | <0.001 | 1,055 (79.6) | 566 (81.3) | 0.66 |
| 2 | 467 (14.2) | 294 (16.1) | 143 (11.6) | 216 (16.3) | 104 (14.9) | ||
| ≥3 | 101 (2.9) | 69 (3.8) | 20 (1.6) | 54 (4.1) | 26 (3.7) | ||
Values are counts and % if not otherwise indicated. EBRT: external beam radiotherapy.