Table 1.
Cox proportional hazard models for prognostic factors
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (≥ 65/<65) | 1.45 (0.69–3.04) | 0.33 | 1.93 (0.87–4.25) | 0.10 |
| Sex (male/female) | 1.03 (0.73–1.47) | 0.85 | - | |
| Histologic grade (G3/G1+G2) | 1.28 (0.62–2.68) | 0.50 | - | |
| Tumor size (≥ 3cm/<3cm) | 1.90 (0.94–3.84) | 0.07 | 2.34 (1.11–4.94) | 0.03 |
| pT (pT3/pT1+pT2) | 1.74 (0.24–12.9) | 0.59 | - | |
| pN (pN1/pN0) | 1.44 (0.69–2.99) | 0.33 | - | |
| Margin (R1/R0) | 1.23 (0.47–3.22) | 0.67 | - | |
| LVI (positive/negative) | 2.11 (0.91–4.88) | 0.08 | - | |
| Wnt/β-catenin (high/low) | 2.75 (1.03–7.32) | 0.04 | 3.16 (1.19–8.40) | 0.02 |
Hazard ratio >1 indicates an increased risk of death for the first of the two groups indicated for each variable. P values are from Chi-square test using the Cox proportional hazards model. Only those variables retained in the model after backward selection are shown for the multivariate analysis. Abbreviations: HR, hazard ratio; CI, confidence interval; LVI, lymphvascular invasion.