Table 1. Definitions of phases of persistent HBV infection.
Phase | HBeAg status | HBV DNA (lU/ml) | ALT* (U/L) |
immune tolerance (IT) | (+) | >107 | <ULN |
immune clearance (IC) | (+) | >2000 | >2× ULN |
low-replicative (LR) | (−) | <2000 | <ULN |
HBeAg(-) hepatitis (ENH) | (−) | >2000 | >2× ULN |
*In IT and LR groups patients with ALT activity of <1.5 ULN were accepted if no inflammation in liver biopsy was observed. In IC and ENH groups patients with ALT activity of >ULN were accepted if significant inflammation.