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. 2014 Feb 13;9(2):e89046. doi: 10.1371/journal.pone.0089046

Table 1. Definitions of phases of persistent HBV infection.

Phase HBeAg status HBV DNA (lU/ml) ALT* (U/L)
immune tolerance (IT) (+) >107 <ULN
immune clearance (IC) (+) >2000 >2× ULN
low-replicative (LR) (−) <2000 <ULN
HBeAg(-) hepatitis (ENH) (−) >2000 >2× ULN

*In IT and LR groups patients with ALT activity of <1.5 ULN were accepted if no inflammation in liver biopsy was observed. In IC and ENH groups patients with ALT activity of >ULN were accepted if significant inflammation.