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. 2014 Feb 13;9(2):e89109. doi: 10.1371/journal.pone.0089109

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© 2014 Wadood et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The amino acid position for the domain and sub-domain is indicated as a number either starting from the 1st amino acid of the entire polyprotein (the number at the top) or starting from the 1st amino acid of the NS3 or NS4A (the number at the bottom). On the NS3/4A protease, the catalytic triad, namely His-1083, Asp-1107 and Ser-1165 of the polyprotein (or His-57, Asp-81 and Ser-139 of the NS3), is indicated as “”. The reddish box in the NS4A indicates the 14-amino acid central hydrophobic region of NS4A (amino acids 1678–1691 of the polyprotein or amino acids 21–34 of the NS4A), which has been shown to be sufficient for activation of the NS3 protease activity [17].

Inline graphic — The amino acid position for the domain and sub-domain is indicated as a number either starting from the 1st amino acid of the entire polyprotein (the number at the top) or starting from the 1st amino acid of the NS3 or NS4A (the number at the bottom). On the NS3/4A protease, the catalytic triad, namely His-1083, Asp-1107 and Ser-1165 of the polyprotein (or His-57, Asp-81 and Ser-139 of the NS3), is indicated as “”. The reddish box in the NS4A indicates the 14-amino acid central hydrophobic region of NS4A (amino acids 1678–1691 of the polyprotein or amino acids 21–34 of the NS4A), which has been shown to be sufficient for activation of the NS3 protease activity [17].