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prt transcription regulates pho1 expression in response to phosphate. (A) pho1 levels are induced in the absence of phosphate. Under these conditions, prt is not transcribed. (B) In the presence of phosphate, transcription of prt leads to deposition of H3K9me2 marks at pho1. This requires Mmi1, Red1, Clr4, and the RITS complex. The resulting prt is degraded by the exosome. Furthermore, prt requires the exosome and Mmi1 for proper transcription termination coupled to turnover.
